Research

  • Research Overview

    We leverage systems biology to make fundamental contributions to human health.  We do both basic and applied science, with a major focus on translating our science to positively impact society. We are interested in the optimization of wellness, the minimization of disease, the reversal of disease in its earliest stages, the precise diagnosis of disease when it occurs, and the development of treatments.  These are all deeply data-driven pursuits, and we have spent…

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  • Molecular Signatures of Disease

    Molecular Signatures of Disease Disease Classification based on high-throughput expression data With the goal of developing novel methods for disease classification, we have implemented the relative expression classification algorithms, top-scoring pair  (TSP) and top-scoring triplet (TST), for the graphics processing unit (GPU). The GPU is a specialized hardware most commonly associated with gaming applications. However, with the NVIDIA’s release of the Compute Unified Device Architecture (CUDA), the GPU became a…

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  • Integrated Network Modeling

    Integrated Network Modeling High-throughput experimental technologies have enabled the identification and quantification of biological components at unprecedented scale, from genes and proteins to cells and tissues. Collectively, these technologies provide a parts list for biological systems. Computational systems biology employs an integrative approach to characterize biological systems, in which interactions among all components in a system are described mathematically to establish a computable model that cohesively integrates data. For multiple…

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  • 100K Wellness Project

    The sequencing of the human genome promised to revolutionize diagnosis and treatment of disease. This revolution had as its ultimate goal personalized and predictive medicine, in which treatment is tailored to each individual patient as informed by his or her own unique genome sequence. More recently the precision and cost-effectiveness of additional ‘omic technologies, such as metabolomics and proteomics, have increased dramatically, and their potential to personalized medicine has become…

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