News

Turn Health Care Right-Side Up: Focus On Wellness Not Disease

“Another vision for health care is emerging — one that is focused on wellness rather than disease; one that is proactive instead of reactive; one that takes a systems approach to biology and medicine rather than studying one gene, one cell or one protein at a time.” Read this Psychology Today story penned by ISB’s Lee Hood and Nathan Price.

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Dr. Jim Heath Takes Helm of ISB, Looks Toward the Future

Jim Heath took over as president of Institute for Systems Biology on January 1. To fully appreciate Heath’s relationship with ISB, you have to go back to its early days – shortly after the research organization was founded in 2000.

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Key Strategies for Implementing Proteomics-Based Tests Across Disease States Highlighted in Current Opinion in Biotechnology

ISB, Integrated Diagnostics and Sera Prognostics just announced a paper entitled, “The building blocks of successful translation of proteomics to the clinic,” by Leroy Hood and colleagues published online in Current Opinion in Biotechnology.

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Clinical Trial Explores the Effects of Health Coaching on Cognitive Function in Patients with Early-Stage Alzheimer’s

Institute for Systems Biology (ISB) is among several organizations conducting a clinical trial testing how health coaching affects the cognitive function of patients with early-stage Alzheimer’s disease and analyzing longitudinal, multi-omic data to explore transitions in cognitive function over time.

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High School Scientist Targets Sepsis, Earns $25,000 Scholarship Along the Way

Sriharshita Musunuri, 17, is looking to find and stop what causes sepsis, the top killer in American hospitals. She is collaborating with several ISB staff members, including mentor Chris Lausted, and just earned a $25,000 scholarship for her work.

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Lessons I Learned from My 17 Years as ISB President

Lee Hood co-founded Institute for Systems Biology in 2000, and has served as president of the institution since; on January 1, 2018, he left that role to serve as chief science officer of Providence St. Joseph Health. Here, Hood shares the many lessons he learned from 17 years at the helm of ISB.

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2017 Undergrad Interns

Summer 2017 brought a fresh cohort of undergraduate students interested in exploring ISB’s research in the Summer Undergraduate Research Experience Program. Each intern worked with a mentor on a research project and participated in learning experiences aimed at expanding his or her skills. Several of the interns worked in the group with mentors from the Hood-Price Lab. The ISB website has more details and a great collection of photos from…

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ISB Annual Report: Catalyzing A Revolution

ISB’s compass has always been oriented toward the future. Even when we reflect on the past year for each annual report, it’s always through the lens of what’s on the horizon. We are remarkably consistent in that regard, which is in no small part due to our president Dr. Lee Hood, whose vision is perpetually a decade – at least – ahead of everyone else. In this year’s letter, Dr….

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Our Artwork Featured On Cover of Nature Biotechnology

The Institute for Systems Biology and Arivale “Pioneer 100 Study” is featured on the cover of August’s Nature Biotechnology. The artwork was created by ISB’s Associate Director of Communications Allison Kudla in collaboration with contributing author John C. Earls, software engineer in the Hood-Price Lab. About the cover: A subset of statistically significant correlations are extruded in three-dimensional space. Price et al. describe the integration of whole genome sequences; clinical…

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Pioneer 100 Study

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness. Personal, dense, dynamic data clouds enable novel insights into mechanisms of wellness and disease, new approaches to biomarker discovery, and the empowerment of individuals to enhance their own health.

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ISB Engineer Hopes to Save the Sword Ferns in Seattle’s Magnificent Forest

Seattle’s Magnificent Forest at Seward Park is located within one of the nation’s most diverse neighborhoods. The 98118 zip code in southeast Seattle is home to people of all socioeconomic classes including groups of immigrants who speak more than 60 languages. Seward Park serves as an urban oasis for the community to enjoy nature, easy hikes, and access to the expansive Lake Washington. The park’s Magnificent Forest, so called because…

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Spotlight: Alison Paquette, Research Scientist

Congratulations to Alison Paquette who recently was promoted to Research Scientist in the Price Lab. Alison received her PhD in Experimental and Molecular Medicine at the Geisel School of Medicine at Dartmouth. She is interested in identifying molecular biomarkers that may predict preterm birth and adverse neonatal outcomes such as preeclampsia. “Pregnancy complications are not very well understood, and we are amongst the only labs really taking a systems biology…

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New Publication in Cell Systems

April 25, 2017 A Cell-Surface Membrane Protein Signature for Glioblastoma 3 bullets: Using integrated protein and gene expression data, ISB researchers developed a 33-gene signature for glioblastoma, an aggressive form of brain cancer. Glioblastoma gene signatures are associated with TGF-b signaling and cancer invasion. Researchers think that some of the glioblastoma gene signatures have the potential to be used as blood biomarkers for this aggressive cancer. Read the full summary…

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Institute for Systems Biology recruits technology pioneer James Heath as President

The Institute for Systems Biology has named James Heath, PhD, as its new president, effective January 2018. Heath is widely recognized as one of the world’s most accomplished scientists, working on fundamental problems at the interface of the chemical, physical, biological, and biomedical sciences, with focus areas of molecular biotechnologies and oncology. ISB’s co-founder and president Lee Hood, MD, PhD, was appointed senior vice president and chief science officer at…

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New Paper on Huntington’s Disease

Feb. 27, 2017 ISB researchers and colleagues from several institutes published a new study today in Human Molecular Genetics. The key points of the study “High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds” are: A multi-institute collaboration mapped in high resolution the earliest effects of the Huntington’s disease mutation in mice. The study included four different genetic…

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How Scientific Wellness will drive the future of health

‘Hyper Wellbeing’ is a summit to foster an emerging consumer technology industry. Consumer data-driven health, wellness and lifestyle optimization plus disease risk reduction. It represents a power shift towards the consumer and the future of mobile, wearables, health and wellness. Nathan Price presented at the Wellness as a Service World Summit, which took place on 14th November 2016 at the Computer History Museum (1401 N. Shoreline Blvd. Mountain View, CA…

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New video for the Institute for Systems Biology

The Institute for Systems Biology is a nonprofit biomedical research organization based in Seattle, Washington. It was founded in 2000 by systems biologist Leroy Hood, immunologist Alan Aderem, and protein chemist Ruedi Aebersold. ISB was established on the belief that the conventional models for exploring and funding breakthrough science have not caught up with the real potential of what is possible today. ISB serves as the ultimate environment where scientific…

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Wilke Cohen Lyme Disease Project Update & Site Visit

It has been a year of milestones for the Wilke Cohen Lyme Disease Project. ISB received a transformational, multi-year pledge of $3 million from the Steven & Alexandra Cohen Foundation (read press release) and another magnanimous gift from Jeff and Liesl Wilke, who spearheaded the launch of the project in 2015. Our research team was also thrilled to be able to host Jeff and Liesl Wilke and Alex Cohen for…

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